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Diagnosis of Depressive Disorder Malinger Using the Niacin Skin Response Test (NSRT)
Sponsor: Air Force Military Medical University, China
Summary
This study will explore the specific response characteristics of the niacin skin response test in the population with depressive disorder malinger. The investigators expect that depressive disorder malinger can be discriminated by the niacin skin reaction test.
Official title: Biological Diagnostic Techniques for the Diagnosis of Depressive Disorders Malinger Based on the Niacin Skin Response Test (NSRT)
Key Details
Gender
MALE
Age Range
18 Years - 60 Years
Study Type
OBSERVATIONAL
Enrollment
410
Start Date
2024-05-01
Completion Date
2026-05-01
Last Updated
2024-04-24
Healthy Volunteers
Yes
Conditions
Interventions
Niacin skin reaction test
Nicotinic skin reaction, also known as nicotinic flush reaction, occurs when a solution of nicotinic acid methyl ester briefly contacts the skin. Following penetration through the skin barrier into the subcutaneous tissue, it generates nicotinic acid (vitamin B3). Under the action of phospholipase A2 (PLA2), cyclooxygenase (COX), and other enzymes, arachidonic acid (AA) on the cell membrane is cleaved to produce prostaglandins, leading to local vasodilation, increased blood perfusion, and the transient appearance of erythema on the skin.
Locations (1)
Air Force Medical Center
Beijing, Beijing Municipality, China