Clinical Research Directory

Inclusion Criteria: 1. Age ≥ 40 years old; 2. Meet the diagnostic criteria for idiopathic Parkinson's disease (MDS Diagnostic Criteria for Parkinson's Disease (2015 Edition))\[1\]; 3. Have no history of drug adjustment within 4 weeks before treatment and the entire study period; 4. The MDS-UPDRS Ⅲ score ≥8, and the Hoehn-Yahr rating is 1-4; 5. MMSE ≥22，able to cooperate with the completion of behavioral tests and transcranial magnetic stimulation therapy. Exclusion Criteria: 1. Previously head MRI/CT was focal brain injury or severe leukoencephalopathy (Fazekas grade 3 and above); 2. Various secondary parkinsonism syndromes (vascular parkinsonism, Parkinsonism combined with parkinsonism, drug parkinsonism, etc.); 3. Severe craniocerebral trauma, received craniocerebral surgery or deep brain stimulation treatment; 4. There are ferromagnetic implants in the body, such as cochlear implants, cardiac pacemakers, etc. 5. The person has a history of epilepsy, unexplained loss of consciousness, or are taking anticonvulsant drugs to treat epileptic seizures; 6. Diagnosed with a neuropsychiatric disorder other than PD 7. Have a history of drug abuse or drug use; 8. Participants in any clinical trial within the previous 6 month; 9. Pregnant/lactating women or subjects (including men) who have a birth plan within 6 months; 10. Other conditions deemed unsuitable for inclusion by the investigator.