Clinical Research Directory

Inclusion Criteria: * The subject signed the informed consent form; * The subject is ≥ 18 and ≤ 80 years old at surgery; * The subject is in need of a tooth extraction prior to implant placement; * All four bony walls are preserved after extraction; * Minimum 8mm height of bone; * Minimum 7mm thickness of lingual vestibular; * The subject is willing and able to comply with all investigation related procedures (such as exercising oral hygiene and attending all follow-up visits); * Full-mouth bleeding score (FMBS) lower than 25%; * Full-mouth plaque score (FMPI) lower than 25%. Exclusion Criteria: * Subject with an acute infection (abscess) at the surgical site; * Subject with untreated periodontitis or periodontal disease; * Subject with autoimmune diseases or subjects that had received or were currently receiving treatment with antiresorptive drugs (e.g., bisphosphonates), or steroid therapy; * Subject who is pregnant or breastfeeding; * Subjects is a heavy smoker (\>10 cigarettes a day); * Subject with an inability to conduct basic oral hygiene (poor oral hygiene and motivation); * Subject with metabolic diseases (diabetes, hyperparathyroidism, osteomalacia); * Subject with severe renal dysfunction and severe liver disease; * Subject with known severe osteoporosis; * Subject with multiple sclerosis and/or acromegaly; * Subject follows radiotherapy; * Subject with psychiatric disorders or under substance abuse (drug or alcohol); * Subject who participates in other clinical trials interfering with the present protocol; * Mucosal diseases in the areas to be treated.