Clinical Research Directory
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The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
Sponsor: Eli Lilly and Company
Summary
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m\^2 or higher and Atherosclerotic Cardiovascular Disease and/or chronic kidney disease. The study will last for about 5 years. Participants will have up to 27 clinic visits with the study doctor.
Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Event-Driven Study to Investigate the Effect of Retatrutide on the Incidence of Major Adverse Cardiovascular Events and Major Adverse Kidney Events in Participants With Body Mass Index ≥27 kg/m2 and Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease
Key Details
Gender
All
Age Range
45 Years - Any
Study Type
INTERVENTIONAL
Enrollment
10000
Start Date
2024-04-30
Completion Date
2029-02
Last Updated
2026-10-08
Healthy Volunteers
No
Interventions
Retatrutide
Administered SC
Placebo
Administered SC
Locations (742)
Alabama Kidney Research
Alabaster, Alabama, United States
Central Research Associates
Birmingham, Alabama, United States
Alliance for Multispecialty Research, LLC
Daphne, Alabama, United States
Nephrology Consultants
Huntsville, Alabama, United States
Alliance for Multispecialty Research, LLC
Mobile, Alabama, United States
Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC
Gilbert, Arizona, United States
Sun City Clinical Research
Glendale, Arizona, United States
Arizona Kidney Disease & Hypertension Center (AKDHC) - Thunderbird
Glendale, Arizona, United States
Helios Clinical Research - SAZ-PDV-026
Paradise Valley, Arizona, United States
Banner University Medical Center Phoenix
Phoenix, Arizona, United States
Elite Clinical Studies, LLC
Phoenix, Arizona, United States
Absolute Clinical Research
Phoenix, Arizona, United States
Scottsdale Clinical Trials
Scottsdale, Arizona, United States
Clinical Research Institute of Arizona (CRI) - Sun City West
Sun City West, Arizona, United States
Synexus Clinical Research US, Inc./Orange Grove Family Practice
Tucson, Arizona, United States
Cardiology and Medicine Clinic
Little Rock, Arkansas, United States
Trident Clinical Research Services, Inc.
Apple Valley, California, United States
Invivo - Bakersfield
Bakersfield, California, United States
American Institute of Research
Beverly Hills, California, United States
Hope Clinical Research, Inc.
Canoga Park, California, United States
Valley Clinical Trials, Inc.
Covina, California, United States
North Coast Cardiology
Encinitas, California, United States
Neighborhood Healthcare Institute of Health
Escondido, California, United States
HB Clinical Trials - Fountain Valley
Fountain Valley, California, United States
Care Access - Huntington Beach
Huntington Beach, California, United States
Irvine Clinical Research
Irvine, California, United States
Scripps Whittier Diabetes Institute
La Jolla, California, United States
Long Beach Research Institute
Long Beach, California, United States
Ark Clinical Research
Long Beach, California, United States
North America Research Institute
Lynwood, California, United States
Valley Clinical Trials, Inc.
Northridge, California, United States
Desert Oasis Healthcare Medical Group
Palm Springs, California, United States
California Liver Research Institute
Pasadena, California, United States
Western University of Health Sciences
Pomona, California, United States
California Kidney Specialists
San Dimas, California, United States
Southern California Clinical Research
Santa Ana, California, United States
Care Access - Santa Clarita
Santa Clarita, California, United States
Encompass Clinical Research
Spring Valley, California, United States
Valiance Clinical Research
Tarzana, California, United States
Care Access - Thousand Oaks
Thousand Oaks, California, United States
Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.
Toluca Lake, California, United States
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, United States
UCLA South Bay Endocrinology
Torrance, California, United States
InvivoCure
Van Nuys, California, United States
National Institute of Clinical Research (NICR) - High Desert
Victorville, California, United States
Synexus Clinical Research US, Inc.
Vista, California, United States
Millennium Clinical Trials
Westlake Village, California, United States
Western Nephrology
Arvada, Colorado, United States
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
Cardiology Associates of Fairfield County, P.C.
Stamford, Connecticut, United States
Chase Medical Research, LLC
Waterbury, Connecticut, United States
Omega Research Orlando
Altamonte Springs, Florida, United States
Excel Medical Clinical Trials
Boca Raton, Florida, United States
American Research Institute
Cutler Bay, Florida, United States
Fleming Island Center for Clinical Research
Fleming Island, Florida, United States
Jellinger and Lerman, MD PA dba The Center for Diabetes and Endocrine Care
Fort Lauderdale, Florida, United States
Florida Kidney Physicians - Fort Lauderdale
Fort Lauderdale, Florida, United States
East Coast Institute for Research, LLC
Jacksonville, Florida, United States
Lakeview Institute of Clinical Research
Leesburg, Florida, United States
Flourish Research - Miami, LLC
Miami, Florida, United States
New Age Medical Research Corporation
Miami, Florida, United States
Onhealth Research Center
Miami, Florida, United States
Inpatient Research Clinic
Miami Lakes, Florida, United States
CTR Oakwater, LLC
Orlando, Florida, United States
Florida Kidney Physicians, LLC
Port Charlotte, Florida, United States
Florida Kidney Physicians - Tampa
Riverview, Florida, United States
Cardiovascular Center of Sarasota
Sarasota, Florida, United States
Care Access - Tamarac
Tamarac, Florida, United States
MOORE Clinical Research, Inc. d/b/a TrueBlue Clinical Research
Tampa, Florida, United States
Care Access - Tampa
Tampa, Florida, United States
American Clinical Trials - Acworth
Acworth, Georgia, United States
Atlanta Diabetes Associates
Atlanta, Georgia, United States
Emory University School of Medicine
Atlanta, Georgia, United States
Fides Clinical Research
Atlanta, Georgia, United States
Southeastern Clinical Research Institute
Augusta, Georgia, United States
American Clinical Trials - Douglasville
Douglasville, Georgia, United States
Center for Advanced Research & Education
Gainesville, Georgia, United States
The Jones Center Clinical Research
Macon, Georgia, United States
North Georgia Clinical Research
Woodstock, Georgia, United States
Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois, United States
Clinical Investigation Specialists
Gurnee, Illinois, United States
Nephrology Associates of Northern Illinois and Indiana (NANI) - Hinsdale
Hinsdale, Illinois, United States
Accellacare - DuPage
Lombard, Illinois, United States
Alliance for Multispecialty Research, LLC
Niles, Illinois, United States
Rockford Nephrology Associates
Rockford, Illinois, United States
Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
Springfield, Illinois, United States
Qualmedica Research, LLC
Evansville, Indiana, United States
Nephrology Associates of Northern Illinois and Indiana (NANI) - Fort Wayne
Fort Wayne, Indiana, United States
Indiana University Health Methodist Hospital
Indianapolis, Indiana, United States
Nephrology Associates of Northern Illinois and Indiana - IKS - Indianapolis South
Indianapolis, Indiana, United States
Care Access - South Indianapolis
Indianapolis, Indiana, United States
Reid Physician Associates
Richmond, Indiana, United States
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, United States
The University of Kansas - Clinical Research Center
Fairway, Kansas, United States
Alliance for Multispecialty Research, LLC
Newton, Kansas, United States
Cotton O'Neil Clinical Research Center
Topeka, Kansas, United States
Cotton O'Neil Diabetes & Endocrinology
Topeka, Kansas, United States
Qualmedica Research
Bowling Green, Kentucky, United States
Alliance for Multispecialty Research, LLC
Lexington, Kentucky, United States
Monroe Biomedical Research - Louisville
Louisville, Kentucky, United States
Care Access - Lake Charles
Lake Charles, Louisiana, United States
IMA Clinical Research Monroe - Armand
Monroe, Louisiana, United States
Alliance for Multispecialty Research, LLC
New Orleans, Louisiana, United States
Sinai Hospital Of Baltimore
Baltimore, Maryland, United States
Care Access - Baltimore
Baltimore, Maryland, United States
Ascension Saint Agnes Heart Care
Baltimore, Maryland, United States
MedStar Good Samaritan Hospital
Baltimore, Maryland, United States
Jadestone Clinical Research
Beltsville, Maryland, United States
Anderson Medical Research
Ft. Washington, Maryland, United States
MedStar Health Research Institute (MedStar Physician Based Research Network)
Hyattsville, Maryland, United States
NECCR PrimaCare Research
Fall River, Massachusetts, United States
Care Access - Quincy
Quincy, Massachusetts, United States
Revival Research Institute, LLC
Dearborn, Michigan, United States
Elixia MKC, LLC
Pontiac, Michigan, United States
Lake Michigan Nephrology
Saint Joseph, Michigan, United States
Great Lakes Research Institute
Southfield, Michigan, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, United States
StudyMetrix Research
City of Saint Peters, Missouri, United States
Alliance for Multispecialty Research, LLC
Kansas City, Missouri, United States
Clinvest Headlands Llc
Springfield, Missouri, United States
Mercury Street Medical Group, PLLC
Butte, Montana, United States
Boeson Research MSO
Missoula, Montana, United States
Henderson Clinical Trials
Henderson, Nevada, United States
DaVita Clinical Research - Las Vegas
Las Vegas, Nevada, United States
Excel Clinical Research, LLC
Las Vegas, Nevada, United States
Alliance for Multispecialty Research, LLC
Las Vegas, Nevada, United States
Advanced Biomedical Research of America - South Eastern Avenue
Las Vegas, Nevada, United States
Vector Clinical Trials
Las Vegas, Nevada, United States
Albany Medical College, Division of Community Endocrinology
Albany, New York, United States
Capital Cardiology Associates
Albany, New York, United States
Westchester Medical Center Advanced Physicians Service
Kingston, New York, United States
St. Francis Hospital & Heart Center
New Hyde Park, New York, United States
NYU Langone Health
New York, New York, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Saratoga Clinical Research
Saratoga Springs, New York, United States
Care Access - Fayetteville
Fayetteville, North Carolina, United States
Medication Management
Greensboro, North Carolina, United States
Physician's East Endocrinology
Greenville, North Carolina, United States
IMA Clinical Research - Lenoir
Lenoir, North Carolina, United States
West Clinical Research
Morehead City, North Carolina, United States
Accellacare - Raleigh
Raleigh, North Carolina, United States
Accellacare - Wilmington - 1917 Tradd Court
Wilmington, North Carolina, United States
Advanced Medical Research
Maumee, Ohio, United States
Alliance for Multispecialty Research, LLC
Norman, Oklahoma, United States
Heritage Valley Multispecialty Group, Inc
Beaver, Pennsylvania, United States
Northeast Clinical Research Center
Bethlehem, Pennsylvania, United States
Capital Area Research, LLC
Camp Hill, Pennsylvania, United States
Geisinger Medical Center
Danville, Pennsylvania, United States
Lancaster General Hospital
Lancaster, Pennsylvania, United States
Clinical Renal Associates Ltd.
Media, Pennsylvania, United States
Tristar Clinical Investigations
Philadelphia, Pennsylvania, United States
Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair
Pittsburgh, Pennsylvania, United States
Guthrie Medical Group, P.C.
Sayre, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States
Walker Family Care
Little River, South Carolina, United States
Care Access - Mauldin
Mauldin, South Carolina, United States
Circle Clinical Research
Sioux Falls, South Dakota, United States
Alliance for Multispecialty Research, LLC
Knoxville, Tennessee, United States
Care Access - Memphis 2
Memphis, Tennessee, United States
IMA Clinical Research Austin
Austin, Texas, United States
Headlands Research - Brownsville
Brownsville, Texas, United States
South Texas Clinical Research
Corpus Christi, Texas, United States
Private Practice - Dr. Osvaldo A. Brusco
Corpus Christi, Texas, United States
Baylor Soltero CV Research Center
Dallas, Texas, United States
Velocity Clinical Research, Dallas
Dallas, Texas, United States
North Texas Endocrine Center
Dallas, Texas, United States
Renal Disease Research Institute
Dallas, Texas, United States
UT Southwestern Medical Center
Dallas, Texas, United States
Soma Clinical Trials
Denison, Texas, United States
South Texas Research Institute
Edinburg, Texas, United States
Medresearch Inc
El Paso, Texas, United States
Diabetes and Thyroid Center of Ft. Worth
Fort Worth, Texas, United States
Valley Institute of Research - Fort Worth
Fort Worth, Texas, United States
Juno Research
Houston, Texas, United States
Biopharma Informatic, LLC
Houston, Texas, United States
Aqua Research Institute
Houston, Texas, United States
Northwest Houston Cardiology - Cypress