Clinical Research Directory

Inclusion Criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: * Age 20-70 years * BMI ≥ 28 and \< 40 kg/m2 * Weight stable for at least 3 months * Normal blood pressure (systolic blood pressure 100-140 mmHg, diastolic blood pressure 60-90 mmHg) * One or more of the following criteria to determine disturbed glucose/insulin homeostasis * Fasting glucose 5.6-6.9 mmol/L * Two-hour glucose of 7.8-11.1 mmol/L * HOMA-IR ≥ 2.2 * HbA1c (5.7-6.4%) Exclusion Criteria: * Diabetes mellitus (type 1 or 2) * Cardiovascular disease: including no history or myocardial infarction, heart failure, arrhythmias * Pulmonary disease: no history of chronic obstructive pulmonary disease, emphysema, bronchitis, asthma * Kidney (e.g. kidney failure) or liver (e.g. cirrhosis, non-alcoholic fatty acid) malfunction * Gastrointestinal disease (no inflammatory bowel disease, irritable bowel syndrome or digestive disorders) or a history of abdominal surgery (except appendectomy and cholecystectomy) * Autoimmune disease * Any other diseases affecting glucose and/or lipid metabolism or use of any medication that influence glucose or fat metabolism and inflammation * Ongoing disease or any disease with a life expectancy ≤ 5 years * Abuse of products; alcohol (\>15 units per week) and drugs, excessive nicotine use defined as \>20 cigarettes per week * Regular supplementation of pre- or probiotic products, use of pre- or probiotics, antibiotics and laxatives 3 months prior to the start of the study * Intensive exercise training more than three hours a week * Plan to lose weight or to follow a hypocaloric diet or vegetarian diet * Pregnancy