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RECRUITING
NCT06386315
PHASE2

Reduced Dose Radiotherapy for the Treatment of Indolent Non-Hodgkin Lymphoma

Sponsor: Mayo Clinic

View on ClinicalTrials.gov

Summary

This phase II trial compares the safety, side effects and effectiveness of reduced dose radiation therapy to standard of care dose radiation in treating patients with indolent non-Hodgkin lymphoma. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Standard of care radiation treatment for indolent non-Hodgkin lymphoma is usually delivered in 12 treatments. Studies have shown indolent lymphoma to be sensitive to radiation treatment, however, larger doses have higher rates of toxicities. A reduced radiation dose may be safe, tolerable and/or effective compared to standard of care radiation dose in treating patients with indolent non-Hodgkin lymphoma.

Official title: Reduced Dose Hypofractionated Radiotherapy (3Gy x 3 Fractions) for Indolent Non-Hodgkin Lymphoma (POSEIDON): A Multisite Phase 2 Randomized Trial

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

112

Start Date

2024-05-15

Completion Date

2026-05-30

Last Updated

2025-11-24

Healthy Volunteers

No

Interventions

PROCEDURE

Computed Tomography

Undergo CT or PET/CT

PROCEDURE

Endoscopic Procedure

Undergo endoscopy

RADIATION

Involved-site Radiation Therapy (3 Fractions)

Undergo ISRT in 3 fractions

RADIATION

Involved-site Radiation Therapy (12 Fractions)

Undergo ISRT in 12 fractions

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

OTHER

Questionnaire Administration

Ancillary studies

Locations (7)

Mayo Clinic in Arizona

Scottsdale, Arizona, United States

Mayo Clinic in Florida

Jacksonville, Florida, United States

Mayo Clinic Health System in Albert Lea

Albert Lea, Minnesota, United States

Mayo Clinic Health System - Mankato

Mankato, Minnesota, United States

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Mayo Clinic Health System-Eau Claire Clinic

Eau Claire, Wisconsin, United States

Mayo Clinic Health System-Franciscan Healthcare

La Crosse, Wisconsin, United States