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Reduced Dose Radiotherapy for the Treatment of Indolent Non-Hodgkin Lymphoma
Sponsor: Mayo Clinic
Summary
This phase II trial compares the safety, side effects and effectiveness of reduced dose radiation therapy to standard of care dose radiation in treating patients with indolent non-Hodgkin lymphoma. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Standard of care radiation treatment for indolent non-Hodgkin lymphoma is usually delivered in 12 treatments. Studies have shown indolent lymphoma to be sensitive to radiation treatment, however, larger doses have higher rates of toxicities. A reduced radiation dose may be safe, tolerable and/or effective compared to standard of care radiation dose in treating patients with indolent non-Hodgkin lymphoma.
Official title: Reduced Dose Hypofractionated Radiotherapy (3Gy x 3 Fractions) for Indolent Non-Hodgkin Lymphoma (POSEIDON): A Multisite Phase 2 Randomized Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
112
Start Date
2024-05-15
Completion Date
2026-05-30
Last Updated
2025-11-24
Healthy Volunteers
No
Conditions
Interventions
Computed Tomography
Undergo CT or PET/CT
Endoscopic Procedure
Undergo endoscopy
Involved-site Radiation Therapy (3 Fractions)
Undergo ISRT in 3 fractions
Involved-site Radiation Therapy (12 Fractions)
Undergo ISRT in 12 fractions
Positron Emission Tomography
Undergo PET/CT
Questionnaire Administration
Ancillary studies
Locations (7)
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Mayo Clinic in Florida
Jacksonville, Florida, United States
Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota, United States
Mayo Clinic Health System - Mankato
Mankato, Minnesota, United States
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin, United States
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin, United States