Clinical Research Directory

Inclusion Criteria: * ages of 18-50 * diagnosis of MS by a neurologist according to McDonald 2017 criteria (Carroll, 2018) * Being between 2.5 and 4.5 on the Expanded Disability Status Scale (EDSS) * Not having had an attack in the last 3 months * Absence of spasticity severe enough to affect treatment (spasticity in any joint of the upper extremity and lower extremity is \<2 according to the Modified Ashworth Scale) * Getting ≥ 24 points from the Standardized Mini Mental Test (SMMT) Exclusion Criteria: * hearing or vision problems * pregnancy * Having changed medication in the last 3 months and using medication containing the active ingredient Fampridine * Participating or participating in a regular physiotherapy and rehabilitation program in the last 3 months * other accompanying neurological, orthopedic or vestibular disorders * an upper or lower extremity contracture that prevents exercises * History of epileptic seizure, migraine or vertigo attack in the last 6 months