Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease
Sponsor: Incyte Corporation
Summary
This study will be conducted to determine the preliminary efficacy of axatilimab in combination with ruxolitinib and to assess the contribution of axatilimab to the combination treatment effect in participants with cGVHD.
Official title: A Phase 2, Open-Label, Randomized, Multicenter Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease
Key Details
Gender
All
Age Range
12 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2024-10-11
Completion Date
2029-12-01
Last Updated
2026-03-23
Healthy Volunteers
No
Conditions
Interventions
Axatilimab
Axatilimab will be administered at protocol defined dose.
Ruxolitinib
Ruxolitinib will be administered at protocol defined dose.
Corticosteroids
Corticosteroids will be administered at protocol defined dose.
Locations (70)
Mayo Clinic Hospital
Phoenix, Arizona, United States
City of Hope Medical Center
Duarte, California, United States
University of California-Los Angeles Medl Cntr-Oncology Center Bowyer Clinic
Los Angeles, California, United States
Stanford Cancer Center
Stanford, California, United States
University of Colorado Cancer Center
Aurora, Colorado, United States
Colorado Blood Cancer Institute
Denver, Colorado, United States
Smilow Cancer Center-Yale
New Haven, Connecticut, United States
Mayo Clinic Jacksonville
Jacksonville, Florida, United States
Northwestern University
Chicago, Illinois, United States
The University of Chicago Medicine
Chicago, Illinois, United States
University of Maryland-Greenebaum Cancer Center
Baltimore, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Washington University
St Louis, Missouri, United States
Fred and Pamela Buffett Cancer Center
Omaha, Nebraska, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Weill Cornell Medicine
New York, New York, United States
Mount Sinai Hospital
New York, New York, United States
Cleveland Clinic
Cleveland, Ohio, United States
The Ohio State University
Columbus, Ohio, United States
University of Pennsylvania Abramson Cancer Center
Philadelphia, Pennsylvania, United States
Hillman Cancer Center
Pittsburgh, Pennsylvania, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Md Anderson Cancer Center
Houston, Texas, United States
Fred Hutchinson Cancer Center
Seattle, Washington, United States
University of Washington
Seattle, Washington, United States
Froedtert & the Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Az Sint-Jan Brugge - Oostende Av - Campus Sint-Jan
Bruges, Belgium
Universitair Ziekenhuis Antwerpen (Uza)
Edegem, Belgium
Jessa Ziekenhuis
Hasselt, Belgium
Universitair Ziekenhuis (Uz) Leuven
Leuven, Belgium
Universitaire Ziekenhuis Leuven - Gasthuisberg
Leuven, Belgium
Centre Hospitalier Universitaire (Chu) de Liege
Liège, Belgium
AZ DELTA
Roeselare, Belgium
Arthur J E Child Comprehensive Cancer Centre
Calgary, Alberta, Canada
Princess Margaret Cancer Centre - University Health Network
Toronto, Ontario, Canada
Chu Sainte-Justine
Montreal, Quebec, Canada
Vancouver General Hospital
Vancouver, Canada
Klinikum Der Johann Wolfgang Goethe University
Frankfurt am Main, Germany
Universitatklinikum Freiburg
Freiburg im Breisgau, Germany
Universitatsklinikum Hamburg Eppendorf
Hamburg, Germany
Universitaetsklinikum Jena
Jena, Germany
University Hospital Mannheim
Mannheim, Germany
Universitaetsklinikum Regensburg
Regensburg, Germany
Azienda Socio Sanitaria Territoriale Papa Giovanni Xxiii
Bergamo, Italy
Aou Policlinico S. Orsola-Malpighi
Bologna, Italy
Fondazione Irccs Ca Granda Ospedale Maggiore Policlinico Di Milano Uo Dermatologia
Milan, Italy
Ospedale Pediatrico Bambino Gesu Irccs
Rome, Italy
Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore
Rome, Italy
Irccs Istituto Clinico Humanitas
Rozzano, Italy
A.O.U. Citta Della Salute E Della Scienza Di Torino
Torino, Italy
Hospital General Universitario Vall D Hebron
Barcelona, Spain
Hospital Clinic Barcelona Main
Barcelona, Spain
Hospital Universitario Virgen de La Arrixaca
El Palmar, Spain
Hospital Universitario Virgen de Las Nieves
Granada, Spain
Ico Institut Catala D Oncologia
Granvia de L'hospitalet 199-203, Spain
Hospital General Universitario Gregorio Maranon
Madrid, Spain
Hospital Universitario Ramon Y Cajal
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Regional Universitario de Malaga
Málaga, Spain
Hospital Clinico Universitario de Salamanca
Salamanca, Spain
Hospital Universitario Marques de Valdecilla
Santander, Spain
Hospital Universitario Virgen Del Rocio
Seville, Spain
Hospital Clinico Universitario de Valencia
Valencia, Spain
Hospital Universitari I Politecnic La Fe
Valencia, Spain
Queen Elizabeth Hospital
Birmingham, United Kingdom
Cambridge University Hospitals Nhs Foundation Trust
Cambridge, United Kingdom
University Hospital of Wales
Cardiff, United Kingdom
Queen Elizabeth University Hospital
Glasgow, United Kingdom
St James University Hospital
Leeds, United Kingdom
Clatterbridge Cancer Center
Liverpool, United Kingdom