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The Efficacy and Safety of Third-generation TKIs Combined With Azacitidine and Bcl-2 Inhibitor in Patients With CML-MBP
Sponsor: Peking University People's Hospital
Summary
This is a prospective multi-center study to investigate efficacy and safety of the third generation tyrosine kinase inhibitors (TKIs) combined with azacitidine and B-cell lymphoma-2 (Bcl-2) inhibitor in patients with myeloid blast phase chronic myeloid leukemia (CML-MBP).
Official title: The Efficacy and Safety of Third Generation Tyrosine Kinase Inhibitors Combined With Azacitidine and B-cell Lymphoma-2 Inhibitor in Patients With Myeloid Blast Phase Chronic Myeloid Leukemia
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
30
Start Date
2024-07-01
Completion Date
2027-12-01
Last Updated
2025-06-03
Healthy Volunteers
Not specified
Conditions
Interventions
Ponatinib
Ponatinib is recommended orally (PO) daily continuously on days 1-28 in 28-day cycle. Treatment repeats every 28 days in the absence of disease progression, unacceptable toxicity or HSCT.
Azacitidine
Azacitidine is recommended 75mg/m2 subcutaneously on days 1-7 in 28-day cycle. Treatment repeats every 28 days in the absence of disease progression, unacceptable toxicity or HSCT.
Venetoclax
Venetoclax is recommended orally (PO) daily on days 1-14 in 28-day cycle. Treatment repeats every 28 days in the absence of disease progression, unacceptable toxicity or HSCT.
Olverembatinib
Olverembatinib is recommended orally (PO) every other day on days 1-28 in 28-day cycle. Treatment repeats every 28 days in the absence of disease progression, unacceptable toxicity or HSCT.
Locations (15)
Peking university people's hospital
Beijing, Beijing Municipality, China
Beijing Lu Daopei Hospital
Beijing, China
Chuiyangliu hospital affiliated to tsinghua university
Beijing, China
Sichuan Provincial People's Hospital
Chengdu, China
Nanfang Hospital, Southern Medical University
Guangdong, China
The First Affiliated Hospital of Kunming Medical University
Kunming, China
The First Affiliated Hospital of Nanjing Medical University
Nanjing, China
The First Affiliated Hospital of Guangxi Medical University
Nanning, China
Nanyang Central Hospital
Nanyang, China
Ningbo Medical Center Lihuili Hospital
Ningbo, China
Qilu Hospital of Shandong University
Qilu, China
Chinese Academy of Medical Sciences & Peking Union Medical College Hospital
Tianjin, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Henan Cancer Hospital
Wuhan, China
Xi'an International Medical Center Hospital
Xi'an, China
The First Affiliated Hospital, Zhejiang University School of Medicine
Zhejiang, China