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Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis
Sponsor: Natural Resources Institute Finland
Summary
The prevalence of atopic dermatitis has increased along with urbanization and biodiversity loss. According to biodiversity hypothesis, the main reason is urban lifestyle and reduced contact to microbial diversity. Previous studies indicate association between atopic dermatitis and exposure to natural microbes in childhood. Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis will investigate whether the exposure to microbial diversity in sandbox reduces the symptoms of atopic dermatitis, alters commensal microbiota and modifies immune regulation in children.
Official title: Biodiversity Interventions for Well-being - the Effect of Biodiversity Exposure on Atopic Dermatitis
Key Details
Gender
All
Age Range
2 Years - 5 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2023-05-26
Completion Date
2027-09-30
Last Updated
2024-04-30
Healthy Volunteers
Yes
Interventions
Microbial intervention
Children in microbial intervention arm receive an indoor sandbox containing play sand enriched with organic leaf compost, moss and humus substances. Families also receive an indoor cultivation set including growing box, seeds, spray bottle, plant lamp and microbe rich growing medium containing organic leaf compost, moss, biochar and humus substances.
Placebo
Children in placebo arm receive an indoor sandbox containing visually similar play sand modified with peat with low microbial diversity. Families also receive an indoor cultivation set including growing box, seeds, spray bottle, plant lamp and growing medium containing peat, inorganic fertilizers, and potting gravel with low microbial diversity.
Locations (2)
Natural Resources Institute Finland
Helsinki, Uusimaa, Finland
Tampere University
Tampere, Finland