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RECRUITING

NCT06391684

Flexibility and the Predictive Brain in Autistic Males and Females

Sponsor: University Hospital, Grenoble

View on ClinicalTrials.gov

Summary

The goal of this study is to compare the neural correlates of predictive brain mechanisms during high-level social and non-social flexibility tasks, between autistic and non-autistic males and females. The aim is to better understand if autistic individuals differ from non-autistic individuals in their cognitive flexibility according to the social and predictable nature of the stimuli, at a behavioral and neurofunctional level using the functional Magnetic Resonance Imaging (fMRI). As autistic females usually present a more subtle profile than autistic males, the investigators will also explore if autistic males and females present neurofunctional differences.

Official title: Neurofunctional Specificities in Predictive Processing During High-Level Cognitive Flexibility Tasks in Autistic Males and Females

Key Details

Gender

All

Age Range

18 Years - 50 Years

Study Type

OBSERVATIONAL

Enrollment

Start Date

2025-02-21

Completion Date

2029-04-20

Last Updated

2026-10-02

Healthy Volunteers

Yes

Conditions

Autism Spectrum Disorder

Interventions

BEHAVIORAL

Social/non social; predictable vs unpredictable

Task 1: social predictable vs social unpredictable ; Task2 a. social \& b. non social, predictable/unpredictable (for both)

Inclusion Criteria: For non autistic individuals * Affiliation with social security scheme. * Registration in the national database of individuals willing to participate in research involving human subjects. * Absence of contraindications for MRI. * Signed informed consent before any study-related procedure. * Visual acuity allowing normal perception of stimuli or corrected vision. * Autism Quotient (AQ) (Baron-Cohen et al., 2001) \< 32. For autistic individuals: * Affiliation with social security scheme. * Absence of contraindications for MRI. * Signed informed consent before any study-related procedure. * Visual acuity allowing normal perception of stimuli or corrected vision. * Diagnosis of autism established by a competent professional based on DSM/ICD criteria. Exclusion Criteria: * Any subject with a vascular stent implanted less than 6 weeks before the examination. * Any subject with implanted biomedical material deemed "unsafe" or "not safe" in the list: http://www.mrisafety.com/TheList\_search.asp. * Any acquisition procedure not meeting the conditions required for "conditional" use in subjects with implanted biomedical material classified as "conditional" in the list: http://www.mrisafety.com/TheList\_search.asp. * Any subject with biomedical material such as a cardiac, neuronal, or sensory stimulator (cochlear implant due to the risk of demagnetization, heating, electrode, and artifacts) or a ventricular shunt valve without medical and paramedical supervision trained in MRI performance in these subjects. * Intraocular or intracranial ferromagnetic foreign body near nerve structures (risk of displacement and complications such as ocular or cerebral lesions). * Claustrophobia - Psychiatric or neurological conditions other than those specified. * Existence of a severe general health condition incompatible with the study: cardiac, respiratory, hematological, renal, hepatic, or cancerous. * Alcohol ingestion before the examination. * Persons covered by articles L1121-5 to L1121-8 of the Public Health Code (pregnant or breastfeeding women, minors or adults under legal protection, individuals under administrative or judicial surveillance). * Visual impairments. * Intellectual disability. * Inability to understand research instructions or provide informed consent.

Locations (1)

CHU Grenoble Alpes_DRCI_Pavillon Dauphiné_CS

Grenoble, France