Clinical Research Directory

Inclusion Criteria: 1. Aged 18 or above (subject to the time of signing the informed consent form) , gender is not limited; 2. According to Allergan Infraorbital Rim Scale (AIHS), the subjects were judged by blinded evaluator as having "moderate" or "severe" infraorbital rim hallowing (grade 2-3) in each eye, and both eyes must meet the requirements but do not need to have the same score; 3. The injection investigator believes that the hallowing of the infraorbital rim area of the subject can be corrected to grade 0 or grade 1; 4. Able and willing to follow the investigator's guidance, following the treatment restrictions in this protocol, and completing all the visits of this trial as required ; 5. Able to complete the self-assessment of effectiveness without the use of glasses (contact lenses are accepted if the subject wear contact lenses for all the follow-up visits); 6. Volunteer to participate in this clinical trial and sign the Informed Consent Form. Exclusion Criteria: 1. Atrophy in the infraorbital area; 2. Previous trauma to the infraorbital area, or residual defects, deformities, or scarring in the periorbital or cheek area before screening; 3. The investigator considers that there is a large lower eyelid fat pad that will affect the treatment outcome; 4. The front most part of the eyeball protrudes forward more than the front most part of the cheek; 5. Hyperpigmentation in the infraorbital area (excluding dark circles which are not caused by hyperpigmentation).