Clinical Research Directory

Inclusion Criteria: 1. subjects voluntarily participated and signed a written informed consent form; 2. age ≥18 years, male or female; 3. ECOG PS 0-1; 4. histopathologically diagnosed advanced malignant tumors; 5. at least 1 measurable lesion according to RECIST v1.1 criteria or Lugano (2014) criteria; 6. adequate organ function; Exclusion Criteria: 1. previous treatment with 4-1BB agonist or 4-1BB recombinant fusion protein; 2. received anti-tumor therapy within 4 weeks prior to the first study treatment; 3. history of autoimmune disease; 4. history of other active malignancies within 3 years prior to the first treatment; 5. history of serous cardiovascular events;