Clinical Research Directory

Inclusion Criteria: Inclusion criteria for patient with DOR: * 18 years old ≤ age \< 40 years old, female; * Clinical diagnosis of Diminished Ovarian Reserve: meet both items in twice tests with an interval of at least 4 weeks(tested between 2rd to 4th day of menstrual cycle): 1. 10 IU/L \< FSH \< 20 IU/L, 2. Anti-Müllerian hormone(AMH) \< 1.1ng/mL. * without any mind disease, willing to participate in the study and sign the informed consent. * without any other treatment. Inclusion criteria for healthy participants: * healthy participants who can provide medical examination reports within the past 1 year and have routine physical examination conducted by researchers to confirm that there are no serious underlying diseases of the reproductive system, urinary system, blood, endocrine, nervous system, etc.; * without symptoms of oligomenorrhea or amenorrhea at present; * between the ages of 18 to 40, female; * without any mind disease, volunteering to participate in the study and sign the informed consent. Exclusion Criteria: Exclusion Criteria for patient with DOR * Low or no response to exogenous gonadotropins, or with congenital anomalies in the development of the reproductive tract; * Pregnant or breastfeeding; * Abnormal body temperatures at the moment; * Psychopath, alcoholic, Patient with severe depression, history of substance abuse and severe primary diseases of cardiovascular, liver, kidney and hematopoietic system; * Currently enrolled in other clinical trials or refuse to cooperate with the study protocol. Exclusion Criteria for healthy participants * Patient with mental illness, severe depression, alcohol dependence or a history of drug abuse; * In pregnant or breastfeeding; * abnormal body temperature at present; * Participants who are currently participating in other clinical trials or who do not cooperate with the study protocol.