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COhort of antithrOmbotic Use and cLinical Outcomes in Patients With Atrial Fibrillation (COOL-AF) Phase 2
Sponsor: Mahidol University
Summary
Atrial fibrillation (AF) is a leading cause of cardiovascular mortality and morbidity. Asian patients with AF have a higher rate of major bleeding including intracranial hemorrhage (ICH) compared to non-Asians. Non-vitamin K antagonist oral anticoagulants (NOACs) are the safer drugs compared to warfarin due to a lower rate of ICH, but the rate of NOACs use in many Asian AF is much lower than non-Asian countries due to economic concerns. The purpose of the COhort of antithrOmbotic use and cLinical outcomes in patients with Atrial Fibrillation (COOL-AF) Phase 2 registry is to determine the changes in antithrombotic patterns and the impact on clinical outcomes. The COOL-AF Phase 2 study is a prospective observational multicenter study of patients with known or newly diagnosed non-valvular AF in Thailand. The aim is a sample size is 3680 patients from 33 centers within a 2-years enrollment timeline. Patients will be follow-up every 6 months until 3 years. The study outcomes were death, ischemic stroke/systemic embolism, major bleeding, myocardial infarction, heart failure, and quality of life.
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
4000
Start Date
2024-06-02
Completion Date
2030-06-01
Last Updated
2025-05-09
Healthy Volunteers
No
Conditions
Interventions
No intervention
No intervention
Locations (33)
Faculty of Meddcine Siriraj Hospital, Mahidol University
Bangkok, Bangkok, Thailand
Faculty of Medicine, Chulalongkorn University,
Bangkok, Bangkok, Thailand
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Bangkok, Bangkok, Thailand
Faculty of Medicine, Vajira Hospital, Navamindradhiraj University
Bangkok, Bangkok, Thailand
Phramongkutklao College of Medicine
Bangkok, Bangkok, Thailand
Police General Hospital
Bangkok, Bangkok, Thailand
Central Chest Institute of Thailand
Nonthaburi, Changwat Nonthaburi, Thailand
Faculty of Medicine, Prince of Songkla University
Songkhla, Changwat Songkhla, Thailand
Faculty of Medicine, Chiang Mai University,
Chiang Mai, Chiang Mai, Thailand
Bhumibol Adulyadej Hospital
Bangkok, Thailand
Charoen Krung Pracha Rak Hospital
Bangkok, Thailand
Rajavithi Hospital
Bangkok, Thailand
Prapokklao Hospital (Chanthaburi),
Chanthaburi, Thailand
Nakornping Hospital
Chiang Mai, Thailand
Chiangrai Prachanukroh Hospital
Chiang Rai, Thailand
Chonburi Hospital
Chon Buri, Thailand
Queen Savang Vadhana Memorial Hospital
Chon Buri, Thailand
Faculty of Medicine, Khon Kaen University
Khon Kaen, Thailand
Lampang Hospital
Lampang, Thailand
Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center (MSMC) Srinakharinwirot University
Nakhon Nayok, Thailand
Golden Jubilee Medical Center
Nakhon Pathom, Thailand
Maharat Nakorn Ratchasima Hospital
Nakhon Ratchasima, Thailand
Sawanpracharak Hospital
Nakhon Sawan, Thailand
Faculty of Medicine, Thammasat University, Rangsit Campus
Pathum Thani, Thailand
Buddhachinaraj Hospital
Phitsanulok, Thailand
Faculty of Medicine, Naresuan University
Phitsanulok, Thailand
Vachira Phuket Hospital
Phuket, Thailand
Ratchaburi Hospital
Ratchaburi, Thailand
Sakonnakhon Hospital
Sakon Nakhon, Thailand
Suratthani Hospital
Surat Thani, Thailand
Surin Hospital
Surin, Thailand
Sunpasitthiprasong Hospital
Ubon Ratchathani, Thailand
Udonthani Hospital
Udon Thani, Thailand