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Effect of S. Aureus Skin Decolonization on Disease Severity in Atopic Dermatitis Patients
Sponsor: Boston Children's Hospital
Summary
Our hypothesis is that S. aureus skin decolonization in atopic dermatitis reduces disease severity and favorably alters the function and gene expression of epidermal and immune skin cells that contribute to disease severity.
Key Details
Gender
All
Age Range
6 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2031-01-01
Completion Date
2039-12
Last Updated
2026-03-10
Healthy Volunteers
No
Conditions
Interventions
Skin Cleanser Combination No.1
1. Mupirocin 2% nasal ointment to the anterior nares to be applied twice daily 2. Chlorhexidine 4% topical soap (Hibiclens) to be used every other day in the shower or bath from the neck down and then completely rinsed. 3. Sulfamethoxazole/trimethoprim (Bactrim): one double strength (DS) tablet (800 mg/160 mg) twice per day for adolescents and adults. Dosing for pediatric patients will be calculated to 5 to 6 mg/kg trimethoprim also given twice daily.
Locations (1)
Boston Children's Hospital
Boston, Massachusetts, United States