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NOT YET RECRUITING
NCT06397781
PHASE4

Effect of S. Aureus Skin Decolonization on Disease Severity in Atopic Dermatitis Patients

Sponsor: Boston Children's Hospital

View on ClinicalTrials.gov

Summary

Our hypothesis is that S. aureus skin decolonization in atopic dermatitis reduces disease severity and favorably alters the function and gene expression of epidermal and immune skin cells that contribute to disease severity.

Key Details

Gender

All

Age Range

6 Years - Any

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2031-01-01

Completion Date

2039-12

Last Updated

2026-03-10

Healthy Volunteers

No

Interventions

DRUG

Skin Cleanser Combination No.1

1. Mupirocin 2% nasal ointment to the anterior nares to be applied twice daily 2. Chlorhexidine 4% topical soap (Hibiclens) to be used every other day in the shower or bath from the neck down and then completely rinsed. 3. Sulfamethoxazole/trimethoprim (Bactrim): one double strength (DS) tablet (800 mg/160 mg) twice per day for adolescents and adults. Dosing for pediatric patients will be calculated to 5 to 6 mg/kg trimethoprim also given twice daily.

Locations (1)

Boston Children's Hospital

Boston, Massachusetts, United States