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Virus as Treatment of C. Difficile Infection (VISION)
Sponsor: Copenhagen University Hospital, Hvidovre
Summary
Fecal Virome Transplantation (FVT) has in small studies shown benefit in the treatment of recurrent C. difficile infection. In the VISION study we will treat patients with recurrent C. difficile infection with FVT capsules and compare the treatment with Fecal Microbiota Transplantation (FMT) capsules. Both will be following af standard treatment of antibiotics (Vancomycin)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2024-05-01
Completion Date
2026-12-31
Last Updated
2024-05-03
Healthy Volunteers
No
Conditions
Interventions
Fecal Virome Transplantation
The primary steps of the production of fecal virome transplantation capsules is the same as when producing fecal microbiota transplantation capsules. Through an subsequent proces of filtering bacterial parts of the material are removed. The material, now called fecal virome transplanation material, has then been moved to capsules and stored in -80c untill use.
Fecal microbiota Transplantation
Donor fecal material is mixed with cryoprotectant and NaCl. Following processing the material transfered to capsules and is stored at -80c prior to use.
Locations (1)
Copenhagen University Hospital Hvidovre
Hvidovre, Denmark