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Topical Insulin for Postoperative Wound Healing
Sponsor: Cairo University
Summary
This study aimed to investigate the potential effect of applying topical insulin therapy on the management and healing of postoperative wounds in patients known with type 2 diabetes mellitus (T2DM) and in a parallel group without diabetes. Investigators also studied the effect of topical insulin therapy on the expression of e-cadherin and Ki67, as markers for cellular proliferation and wound repair. The levels of IL-6 and the H2O2-induced DNA damage product, 8-hydroxy-2'-deoxyguanosine (8-OHdG), were assessed as markers for inflammation and oxidative stress. Finally, histomorphological assessment of skin biopsies was also carried out.
Official title: Investigating the Impact of Topical Insulin on Postoperative Wound Healing in Diabetic and Non-Diabetic Patients: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
40 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
74
Start Date
2023-04-16
Completion Date
2024-12-10
Last Updated
2024-08-21
Healthy Volunteers
No
Interventions
Insulin
Insulin is applied as a topical dressing for postoperative wounds and compared to the conventional povidone iodine treatment
Povidone-Iodine
Insulin is applied as a topical dressing for postoperative wounds and compared to the conventional povidone iodine treatment
Locations (1)
Omnia Azmy Nabeh
Cairo, Egypt