Clinical Research Directory

Inclusion Criteria: * Heart Team has confirmed eligibility for both TAVR-explant and redo-TAVR for failed THV * Subject is symptomatic from their failed THV, as demonstrated by NYHA Functional Class ≥II * Subject and the treating physician agree that the subject will return for all required post-procedure follow-up visits * Subject meets the legal minimum age to provide informed consent based on local regulatory requirements. Exclusion Criteria: * Ongoing sepsis, including active endocarditis; * Severe dementia (resulting in either inability to provide informed consent for the trial/procedure, prevents independent lifestyle outside of a chronic care facility, or will fundamentally complicate rehabilitation from the procedure or compliance with follow-up visits); * Other medical, social, or psychological conditions that in the opinion of the Investigator precludes the subject from appropriate consent or adherence to the protocol required follow-up exams; * Pregnancy or intent to become pregnant for the next 12 months; Coronary obstruction risk: \- Patients at risk of coronary obstruction may be enrolled into the randomized cohort if the operators determine that redo-TAVR can be safely accomplished with leaflet modification or other coronary protection strategies.