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RECRUITING
NCT06400472
PHASE1

A Study of LY4170156 in Participants With Selected Advanced Solid Tumors

Sponsor: Eli Lilly and Company

View on ClinicalTrials.gov

Summary

The purpose of this study is to find out whether the study drug, LY4170156, is safe, tolerable and effective in participants with advanced solid tumors. The study is conducted in two parts - phase Ia (dose-escalation, dose-optimization) and phase Ib (dose-expansion). The study will last up to approximately 4 years.

Official title: A First-in-Human, Phase 1a/1b Trial to Assess the Safety, Tolerability and Preliminary Efficacy of LY4170156, an Antibody-Drug Conjugate Targeting Folate Receptor α-Expressing Tumor Cells, in Participants With Selected Advanced Solid Tumors

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

495

Start Date

2024-05-20

Completion Date

2027-04

Last Updated

2026-01-14

Healthy Volunteers

No

Interventions

DRUG

LY4170156

Intravenous

DRUG

bevacizumab

IV

DRUG

carboplatin

IV

DRUG

Itraconazole

oral

DRUG

pembrolizumab

IV

Locations (23)

HonorHealth

Scottsdale, Arizona, United States

University of California, San Diego (UCSD) - Moores Cancer Center

La Jolla, California, United States

South Texas Accelerated Research Therapeutics (START) Midwest

Grand Rapids, Michigan, United States

NYU Langone Health - Long Island

Mineola, New York, United States

New York University (NYU) Clinical Cancer Center

New York, New York, United States

David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center

New York, New York, United States

The Ohio State University (OSU) Wexner Medical Center

Columbus, Ohio, United States

The University of Texas - MD Anderson Cancer Center

Houston, Texas, United States

START Mountain Region

West Valley City, Utah, United States

Cancer Research SA

Adelaide, Australia

Icon Cancer Centre South Brisbane

QLD, Australia

Centre Leon Berard

Lyon, France

Institut de Cancerologie de l'Ouest - site St-Herblain

Saint-Herblain, France

Oncopole Claudius Regaud

Toulouse, France

Istituto Europeo di Oncologia

Milan, Italy

Istituto Clinico Humanitas

Rozzano, Italy

Shizuoka Cancer Center

Shizuoka, Japan

National Cancer Center Hospital

Tokyo, Japan

Cancer Institute Hospital of JFCR

Tokyo, Japan

National Cancer Center

Goyang-si Gyeonggi-do, South Korea

Hospital Universitario Vall d'Hebron

Barcelona, Spain

Hospital Universitario 12 de Octubre

Madrid, Spain

Hospital Clinico Universitario de Valencia

Valencia, Spain