Clinical Research Directory

Age Related Differences in Respiratory Immune Responses in Influenza Virus Infection

Sponsor: Karolinska Institutet

Summary

The goal of this observational study is to understand immune responses to viral airway infection in adults, including the elderly. The main question(s) to answer is/are: Why do some individuals acquire only asymptomatic or mild Influenza A virus (IAV) infection while others become severely ill and even succumb to the same disease? Participants will be asked to donate samples when seeking health care for influenza-like symptoms or if hospitalized for IAV or SARS-CoV-2. Samples asked for are: * Blood sample by venepuncture * Blood sample by capillary sampling * Nasopharyngeal aspirate * Nasopharyngeal swab * Endotracheal tube aspirate * Nasal swab * Nasal curette * Breath Explor (sampling of expired air) Researchers will compare obtained results with the same type of samples from healthy controls.

Official title: Respiratory Immune Responses in Human Influenza Virus Infection Across Age to Understand What Dictates Disease Severity

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Locations (5)