Clinical Research Directory

Inclusion Criteria: 1. chronic hematoma is diagnosed with CT/MRI scan; thickness of hematoma is more than 1 cm; 2. more than 60 years of age or 60 years; 3. MGS-GCS (Markwalder's Grading Scale and Glasgow Coma Scale) is less than or equal to 2; 4. patients have neurological symptom caused by CSDH before surgery, such as headache, dizziness, nausea, vomiting, numbness or weakness of limb, instability to walk, unconsciousness, trouble speaking, insensitive, etc. 5. receive burr hole drainage; 6. sign informed consent voluntarily. Exclusion Criteria: 1. pregnancy or lactation; 2. have hernia of brain or acute massive cerebral infarction that have to perform craniotomy 3. have serous cancer, hemorrhagic disease, cardiac dysfunction and other serious disease that may aggravate patient's condition and impact follow-up; 4. patients can not stay in bed for long-term due to mental illness or spinal disease(kyphotic deformity); 5. CT scan showed that no obvious brain compression or midline shift; no symptom before surgery; neurosurgeon evaluate that patients do not require surgery; 6. have CSDH for more than 1 year or organized hematoma; 7. CSDH caused by over V-P shunting; 8. during burr hole drainage, patients have to perform craniotomy due to acute bleeding or brain hernia; 9. during burr hole drainage, patients have cerebral contusion or drainage catheter insert into brain unexpectedly; 10. have venous thrombosis of lower extremity or pulmonary embolism; 11. cannot regular reexamine within 1 year for any reason; 12. life expectancy less than 1 year; 13. participating other ongoing clinical trial; 14. patients are not qualified for other reason evaluated by two neurosurgeons; 15. have bile reflux gastritis and esophageal diseases.