Clinical Research Directory

Inclusion Criteria: * Ability and willingness to give written informed consent * Diagnosis of chronic limb threatening ischaemia, undergoing one of the following procedures: Infra inguinal bypass, Extra anatomical bypass, Common femoral endarterectomy, Endovascular treatment, Primary amputation Exclusion Criteria: * Patients with active medical conditions deemed an absolute contraindication for undertaking CPET * Ongoing evaluation for coronary artery disease (e.g awaiting stress test or cardiac catheterisation or requiring the up titration of anti anginal medications) * Active arrthymic requiring the initiation or up titration of an anti arrthymic medication * Active congestive cardiac failure requiring the initiation or up titration of diuretic therapy. * Severe cardiac valvular stenosis * Physical disability precluding ability to perform CPETarm * Psychiatric disorder or dementia precluding them from consenting for research and/or undertaking testing and/or follow up