Clinical Research Directory

Inclusion Criteria: 1. Age 18-80 years old; 2. Primary minimal change disease confirmed by renal biopsy (Initial therapy); 3. 24h-UTP\>3.5g/d or PCR\>3500mg/g, and serum albumin\<30g/L; 4. Agree to participate in the project and sign the informed consent. Exclusion Criteria: 1. Secondary minimal change disease; 2. eGFR\<60 mL/min/1.73m2; 3. Had history of mental disease, dysnoesia, serious cardiovascular and cerebrovascular diseases, pulmonary insufficiency, malignant tumors or other major diseases that are not suitable for clinical experiments; 4. Active bleeding in the gastrointestinal tract; 5. Prior treatment with corticosteroids or other immunosuppressants; 6. HBV, HCV, HIV or other untreated infections, congenital or acquired immunodeficiency diseases; 7. Have been vaccinated with live vaccine in the past four weeks; 8. Serum bilirubin \> 3.6mg/dl for at least 1 month or liver function ≥3 times the upper limit of normal value; 9. Allergic to prednisolone, tacrolimus, or ripertamab; 10. Reluctance to use contraception or plan pregnancy/lactation within 6 months of study completion; 11. Had history of alcohol/drug abuse; 12. Unable to give informed consent.