Clinical Research Directory

Gut Microbiome Analysis in Organ Transplant Recipient

Sponsor: Asan Medical Center

Summary

The microbiome acts as an antigen and can induce signaling through receptors like TLRs and NODs. Microbial metabolites can directly act on gut cells or reach other organs systemically. Studies show that the commensal, non-pathogenic microbiota plays an important role in regulating the immune system in various ways: * Promoting differentiation of Th17 cells and ILC3 signaling to regulate IL-17A production * Influencing iNKT cell generation early in life to prevent inflammatory activities * Facilitating CD4+ T cell differentiation and balancing Th1/Th2 responses * Inducing regulatory T cells (Tregs) that promote immune homeostasis * Tregs in Peyer's patches help maintain a microbiome that supports homeostasis The microbiome influences T cells, B cells and immune homeostasis. This has implications for transplantation, where modulating the microbiome could impact the graft's acceptance by affecting the recipient's immune cells that respond to the transplant. In summary, it highlights the microbiome's role in immune regulation and the potential for leveraging this interaction therapeutically, including in the context of transplantation.

Official title: Analysis of Microbiome Changes and Prognostic Association After Solid Organ Transplantation

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