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Microbiome Effects of Extended Use of MI Paste in Elderly Removable Denture Wearers
Sponsor: University of Iowa
Summary
The purpose of this study is to determine if MI Paste affects the bacteria and fungus present within the mouth, as well as to determine if MI Paste increases denture comfort and retention. MI Paste is a water-based topical dental product that is available without a prescription. It is generally used to treat dental/tooth hypersensitivity (sensitive teeth) in patients and/or to help re-mineralize the tooth enamel in patients. Within this study, there is an off-label use for research subjects to apply above the upper denture.
Key Details
Gender
All
Age Range
65 Years - 105 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-08-28
Completion Date
2027-06
Last Updated
2025-11-10
Healthy Volunteers
No
Conditions
Interventions
MI Paste
Sterile swabs will be used to collect plaque from under the subject's upper denture (when the denture is removed) and the subject's mouth tissues. This will be used for genomic DNA, bacteria analysis, and fungus analysis. Subjects will also apply 1 cubic centimeter of MI Paste to the fitting surface on a daily basis for 14 days. Afterward, subjects will return to the clinic for another sterile swab to be collected.
Locations (1)
University of Iowa College of Dentistry
Iowa City, Iowa, United States