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Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The primary objective of the PGL.EXPO-2 study is to test the hypothesis that exposure (occupational, environmental and/or domestic) to succinate dehydrogenase inhibitors (SDHi) could contribute to tumor emergence in subjects carrying a germline mutation in one of the SDHx genes.The primary endpoint will be the proportion of subjects (cases or controls) exposed to SDHi and the association with paraganglioma risk. In addition, a blood sample (10 ml on EDTA) will be proposed to the participants to the study
Official title: Impact of Environmental Exposures on Tumor Risk in Subjects at Risk of Hereditary SDHx-related Paragangliomas - National Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
1300
Start Date
2024-05-01
Completion Date
2028-05-01
Last Updated
2024-05-10
Healthy Volunteers
No
Conditions
Locations (20)
CHU d'Angers
Angers, France
CHU Jean Minjoz Besançon
Besançon, France
Hôpital Louis Pradel
Bron, France
CHU de Caen
Caen, France
Hôpital Michalon - CHU Grenoble
Grenoble, France
CHU de Lille - Hôpital HURIEZ
Lille, France
Hopital de la Conception - Marseille
Marseille, France
CHU de Montpellier - Hôpital Lapeyronie
Montpellier, France
CHU de Nantes
Nantes, France
CHU de Nice -Hôpital Archet 2
Nice, France
Hôpital Pitié-Salpêtrière - APHP
Paris, France
Hôpital Cochin - APHP
Paris, France
Hôpital européen Georges Pompidou - APHP
Paris, France
Hôpital européen Georges Pompidou - APHP
Paris, France
CHU de Poitiers
Poitiers, France
CHU de Rennes - Hôpital Sud
Rennes, France
Hôpitaux universitaire de Strasbourg - Hôpital de Hautepierre
Strasbourg, France
CHU de Toulouse - Hôpita Larrey
Toulouse, France
CHU Bretonneau
Tours, France
Institut Gustave Roussy
Villejuif, France