Clinical Research Directory

Inclusion Criteria: * Participants must meet the diagnostic criteria for MDD as outlined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). * Participants must have a baseline score of 18 or higher on the 24-item Hamilton Depression Rating Scale (HDRS-24). * During the trial's treatment period, participants must be using a single antidepressant medication at a stable dose. * Participants must be between the ages of 18 and 65 years. * Informed consent from both parents and legal guardians is required. Exclusion Criteria: * Individuals with current or history of organic brain disorders or neurological disorders will be excluded from the study. * Participants with a Wechsler Abbreviated Scale of Intelligence (WASI) score of less than 70 will be excluded. * Individuals currently taking antiepileptic drugs, benzodiazepines, or other medications that may affect seizure activity will be excluded from the study. * Those with exposure to ECT, modified ECT, MST, transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), or other neurostimulation treatments in last 6 months will be excluded. * Individuals with cochlear implants, cardiac pacemakers, implanted devices, or metal in the brain will be excluded from participation. * Pregnant or lactating individuals will be excluded from the study. * Individuals currently participating in another concurrent clinical trial will not be eligible for inclusion. * Participants who refuse to provide informed consent to participate in the trial will be excluded. * Other circumstances deemed unsuitable for participation by researchers will result in exclusion.