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Research on the Brain Mechanism of taVNS in Regulating PD Motor Symptoms
Sponsor: The First Affiliated Hospital with Nanjing Medical University
Summary
This study is a double blind comparative study exploring the neural underpinnings of taVNS modulating PD motor deficits. We hypothesize that taVNS might improve PD motor deficits by regulating the balance between excitation and inhibition in the primary motor cortex.
Official title: Research on the Brain Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation in Regulating PD Motor Symptoms
Key Details
Gender
All
Age Range
40 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2024-05-11
Completion Date
2024-09
Last Updated
2024-07-03
Healthy Volunteers
Yes
Conditions
Interventions
Transcutaneous auricular vagus nerve stimulation (active）
Transcutaneous auricular vagus nerve stimulation was conducted by transcutaneous electrical stimulation therapy instrument to the cymba conchae of left ear in the vicinity of the auricular branch vagus nerve. Stimulation parameters: frequency = 20 Hz; pulse width = 500 μs, twice a day, 30 minutes each time.
Transcutaneous auricular vagus nerve stimulation (sham）
In the sham stimulation group, the electrodes were fixed at the left earlobe with the same stimulus parameters. Stimulation parameters: frequency = 20 Hz; pulse width = 500 μs, twice a day, 30 minutes each time.
Locations (1)
the First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China