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MitoQ Treatment of Claudication: Myofiber and Micro-vessel Pathology
Sponsor: University of Nebraska
Summary
In our research, we are delving into whether taking MitoQ for six months can improve the symptoms and function of people diagnosed with peripheral artery disease, especially those who suffer from leg pain while walking, known as intermittent claudication. We will be checking if MitoQ helps people with claudication walk better, be more active every day, feel better about their lives, and if it enhances the health of their leg muscles.
Key Details
Gender
All
Age Range
21 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-06-01
Completion Date
2027-06
Last Updated
2026-02-24
Healthy Volunteers
No
Conditions
Interventions
Walking assessment
Participating patients will undergo the following evaluations at baseline and after six months of treatment with MitoQ or placebo: Assessment of walking impairment: Evaluation of treadmill maximum walking distances, six-minute walking distance, and daily physical activity (average steps taken daily)
QOL Survey
Assessment of quality of life: Survey of Quality of life with the Walking Impairment Questionnaire and Short Form 36
Ankle pressure at rest and after stress
Assessment of leg hemodynamics: Evaluation of post-occlusive ankle pressure and ankle/brachial index
Muscle Oxygen
Evaluation of calf muscle heme oxygen saturation
Serum MitoQ Level
Evaluation of serum concentrations of MitoQ
Needle Biopsy
Needle biopsy of the calf muscle
Locations (1)
VA Medical Center
Omaha, Nebraska, United States