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RECRUITING
NCT06412315
NA

7T Amygdala and Citalopram Study

Sponsor: University of Oxford

View on ClinicalTrials.gov

Summary

The goal of this study is to investigate how a common antidepressant citalopram (which increases the levels of the chemical messenger serotonin), affects how a key area of the brain involved in depression (the amygdala) responds to emotional information. Healthy participants will undergo medical and psychiatric health screening, after which they will be assigned to receive either a single dose of citalopram (20mg) or placebo, and undergo brain scanning (7T fMRI) whilst viewing emotional faces. Since the scan uses high field strength, the investigators will be able to see effects of citalopram on different subfields within the amygdala which will help to understand how citalopram might be working.

Official title: The Effects of Citalopram on the Brain's Response to Faces

Key Details

Gender

All

Age Range

18 Years - 40 Years

Study Type

INTERVENTIONAL

Enrollment

50

Start Date

2025-02-13

Completion Date

2026-10-31

Last Updated

2025-02-21

Healthy Volunteers

Yes

Interventions

DRUG

Citalopram

Participants will receive a single dose (20mg) citalopram. Tablets encapsulated to aid blinding. To take per oral once.

DRUG

Placebo

Participants will receive a single dose of placebo (sucrose). Tablets encapsulated to aid blinding. To take per oral once

Locations (1)

University of Oxford, Department of Psychiatry

Oxford, Oxfordshire, United Kingdom