Clinical Research Directory

Inclusion Criteria: * New diagnosis of nonobstructive coronary artery disease * No known coronary artery disease (no previous coronary revascularization) * CAD-Rads score 1-3 * LDL cholesterol \> 2.0 mmol/l * Life expectancy \>3 years * Signed informed consent Exclusion Criteria: * Post CTA test indication for invasive coronary angiography * Non-evaluable CTA exam * Obstructive coronary disease (One or more coronary stenosis ≥70%, left main \>40%) * Ongoing lipid lowering medical treatment (Patients already on lipid lowering medical therapy can be included if the treatment was initiated \<3 months before the time of the CTA test) * BMI \>40 * Renal insufficiency (eGFR \<40 ml/min) * Allergy to iodinated contrast media * Contraindications to statins (Active liver disease Child-Pugh A, B and C, excessive alcohol consumption) * Participation in a cardiac rehabilitation or lifestyle modification program * Pregnancy