Clinical Research Directory

Inclusion Criteria: 1. Aged 18 to 60 years; 2. Those who have been recently diagnosed with moderate-to- severe OSAHS (AHI ≥ 15 beats/h) and who refuse or cannot tolerate the counter-adverse effects and refuse CPAP therapy after conventional medical advice; 3. Those who have not undergone any physical therapy; 4. Have some communication and comprehension skills and can use a smart phone; 5. Signed informed consent. Exclusion Criteria: 1. BMI \> 35kg/m2; 2. Patients with central and mixed sleep apnea; 3. Those who use sleep aids (including benzodiazepines and non-benzodiazepine sedative-hypnotics, anxiolytics with sleep-aiding effects, antidepressants, antipsychotics) and/or nutritional supplements; 4. Those suffering from acute myocardial infarction, acute tachyarrhythmia, pulmonary edema, severe aortic stenosis and other acute cardiovascular diseases; 5. Those with severe respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung volume limitation (due to obesity, pregnancy, or spinal deformity), or cystic fibrosis, pneumothorax, or alveoli; 6. Those with hypothyroidism; 7. Those with severe ENT disorders such as severe upper airway obstruction (complete nasal congestion, tonsil grade III/IV), tongue-tie (Marchesani's protocol), motor symptoms limiting the tongue, antecedent or presence of temporomandibular joint disorders, and severe craniofacial injuries; 8. Those with inflammation-related systemic diseases (e.g., arthritis, tuberculosis, vasculitis, lupus); 9. Those who suffer from neuromuscular diseases (e.g., Duchenne muscular dystrophy) or diseases of the skeleton that prevent them from performing parallel movements due to exercise; 10. Those who smoke and drink alcohol; 11. Those who have had other sleep apnea treatments within 6 months (e.g., surgical procedures, MAD or CPAP treatments) that may affect the study results; 12. Ongoing clinical trials of drugs or devices in which they are participating; 13. Refusal to sign the informed consent form.