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Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome
Sponsor: University of Colorado, Denver
Summary
Hypothesis: The investigators hypothesize that pulsatile FSH intravenous administration to women with obesity will correct the Reprometabolic Syndrome (RMS) luteal deficiency phenotype. Specific Aim: To test the hypothesis that pulsatile IV administration of FSH will rescue the impaired folliculogenesis and relative hypogonadotropic hypogonadism, characteristic of obesity. The investigators will accomplish this by administering a cycle of pulsatile FSH to women with obesity and comparing their hormone output to a cycle using conventional, daily FSH injection at the identical daily dose. The primary outcome will be luteal phase progesterone excretion.
Key Details
Gender
FEMALE
Age Range
19 Years - 37 Years
Study Type
INTERVENTIONAL
Enrollment
5
Start Date
2024-10-01
Completion Date
2026-11
Last Updated
2024-11-27
Healthy Volunteers
Yes
Conditions
Interventions
Follicle Stimulating Hormone
Pulsatile FSH administration via a portable pump.
Locations (1)
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States