Clinical Research Directory

Inclusion Criteria: * Evidence of a personally signed and dated informed consent document indicating that the patient has been informed of all pertinent aspects of the study; * Age: 18 to 75 years old; an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1; * Has at least one assessable lesion according to Response Evaluation Criteria In Solid Tumors (RECIST) v1.1 criteria; * The main organs function well; * Female patient had no plans to become pregnant and voluntarily took effective contraceptive measures from agree with the study to at least 6 months after the last dose of study drug. Exclusion Criteria: * There were other malignant tumors in 3 years; * Has multiple factors affecting oral medication; * Unalleviated toxicity ≥ grade 1 above CTCAE v5.0 due to any previous therapy, excluding hair loss; * Major surgical treatment, open biopsy and obvious traumatic injury were performed within 28 days before the study, or have not fully recovered from previous surgery, or are expected to require major surgical surgery during the study period; * Arteriovenous thrombotic events occurred within 6 months, such as cerebrovascular accident (including transient ischemic attack, cerebral hemorrhage, cerebral infarction), deep venous thrombosis and pulmonary embolism; * Have a history of psychotropic drug abuse and can not quit or have mental disorders; * Subjects with any severe and / or uncontrolled disease included: active hepatitis, have a history of immunodeficiency; * Has known symptomatic central nervous system metastases and/or cancerous meningitis; * Thoracic/abdominal/pericardial effusion with clinical symptoms or requiring repeated drainage, or drainage for the purpose of receiving treatment within one month after receiving the investigational drug for the first time; * Has participated in other clinical trials within 4 weeks before first dose; * According to the judgement of the investigators, there are other factors that may lead to the termination of the study.