Clinical Research Directory
Browse clinical research sites, groups, and studies.
Alzheimer's Plasma Extension
Sponsor: University of Southern California
Summary
The APEX study is a multicenter, observational study designed to capture longitudinal follow-up of plasma biomarkers and cognitive and functional assessments on individuals who screen failed in the AHEAD study over approximately 4 years. Approximately 1000 participants will be enrolled across three groups: * Group A: Approximately 500 participants who are discordant on screening (plasma positive / Positron Emission Tomography (PET) negative), * Group B: Approximately 250 participants who are concordant on screening (plasma negative / PET negative), and * Group C: Approximately 250 participants selected from the individuals who previously screen failed prior to PET for the AHEAD study with oversampling of racial and ethnic populations underrepresented in Alzheimer's disease (AD) clinical trials. Primary Objectives: * Collect longitudinal cognitive and functional assessments and blood-based biomarker data * Evaluate, characterize, and compare the longitudinal cognitive and functional data between the three groups of participants * Compare longitudinal change across race and ethnicity, sex, and Apolipoprotein E (ApoE) status Exploratory Objectives: • Collect baseline amyloid PET on participants without prior amyloid PET data (Group C)
Key Details
Gender
All
Age Range
55 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
1000
Start Date
2023-09-21
Completion Date
2028-06
Last Updated
2025-06-10
Healthy Volunteers
Yes
Interventions
NAV4694
Amyloid PET imaging with NAV4694 injection
Locations (56)
University of Alabama, Birmingham
Birmingham, Alabama, United States
Banner Alzheimer's Institute
Phoenix, Arizona, United States
Banner Sun Health Research Institute
Sun City, Arizona, United States
University of California, Irvine
Irvine, California, United States
University of Southern California
Los Angeles, California, United States
Stanford University
Palo Alto, California, United States
Sharp Neurocognitive Research Center
San Diego, California, United States
University of California, San Francisco
San Francisco, California, United States
University of California, Davis
Walnut Creek, California, United States
Yale University School of Medicine
New Haven, Connecticut, United States
Georgetown University
Washington D.C., District of Columbia, United States
Howard University
Washington D.C., District of Columbia, United States
Brain Matters Research
Delray Beach, Florida, United States
Mayo Clinic, Jacksonville
Jacksonville, Florida, United States
K2 Medical Research - The Villages
Lady Lake, Florida, United States
K2 Medical Research, LLC
Maitland, Florida, United States
Gonzalez MD & Aswad MD Health Services
Miami, Florida, United States
Wien Center for Clinical Research
Miami Beach, Florida, United States
Charter Research
Orlando, Florida, United States
University of South Florida - Health Byrd Alzheimer Institute
Tampa, Florida, United States
Emory University
Atlanta, Georgia, United States
Northwestern University
Chicago, Illinois, United States
Rush University Medical Center
Chicago, Illinois, United States
Indiana University
Indianapolis, Indiana, United States
University of Kansas
Fairway, Kansas, United States
University of Kentucky
Lexington, Kentucky, United States
Johns Hopkins University
Baltimore, Maryland, United States
Boston University
Boston, Massachusetts, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Headlands Eastern MA LLC
Plymouth, Massachusetts, United States
University of Michigan, Ann Arbor
Ann Arbor, Michigan, United States
Mayo Clinic, Rochester
Rochester, Minnesota, United States
Washington University, St. Louis
St Louis, Missouri, United States
Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas
Las Vegas, Nevada, United States
Mount Sinai School of Medicine
New York, New York, United States
Columbia University
New York, New York, United States
University of Rochester Medical Center
Rochester, New York, United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
Case Western Reserve University
Beachwood, Ohio, United States
Cleveland Clinic Lou Ruvo Center for Brain Health, Ohio
Cleveland, Ohio, United States
Ohio State University
Columbus, Ohio, United States
Central States Research, LLC
Tulsa, Oklahoma, United States
Oregon Health & Science University
Portland, Oregon, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
Butler Hospital Memory and Aging Program
Providence, Rhode Island, United States
Ralph H. Johnson VA Health Care System
Charleston, South Carolina, United States
Vanderbilt University Medical Center Center for Cognitive Medicine
Nashville, Tennessee, United States
University of Texas, Southwestern MC at Dallas
Dallas, Texas, United States
Baylor College of Medicine
Houston, Texas, United States
Houston Methodist Neurological Institute
Houston, Texas, United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States
Eastern Virginia Medical School at Old Dominion University
Norfolk, Virginia, United States
National Clinical Research Inc.
Richmond, Virginia, United States
University of Washington, Memory and Brain Wellness Center
Seattle, Washington, United States
University of Wisconsin
Madison, Wisconsin, United States