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Re-evaluation of the Effect Site Model of the PKPD Propofol Eleveld Model
Sponsor: Universidad del Desarrollo
Summary
in healthy patients undergoing elective surgery, after a very slow induction, using Eleveld's kinetics as a reference, after loss of consciousness (LOC) and intubation, proceed to infuse propofol until 1% burst suppression ratio is obtained. Then return to the LOC concentration. The BISindex predicted by the model and the real one will be evaluated. The evolution of spectral density frequencies over time will also be evaluated.
Official title: the BIS Index Response is Poorly Described by Propofol Effect Site Eleveld's Model After Applying a Perturbation
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2013-09-01
Completion Date
2024-09-15
Last Updated
2024-05-16
Healthy Volunteers
Yes
Interventions
fixed propofol infusion 15 mg/kg/h until 1% BSR (burst suppression ratio)
after a slow induction with propofol to loss of consiousness (LOC), we proceed to give remifentanil TCI and rocuronium and intubate the patient. After 5 min we infuse 15 mg/kg/h until 1%BSR observe in the BIS monitor. Then we reduce the TCI LOC predicted concentration.
Locations (1)
Hospital Base san José de Osorno
Osorno, Chile