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Effect of TCI Propofol on Liver Transplant (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients.
Sponsor: Institute of Liver and Biliary Sciences, India
Summary
Both isoflurane and propofol are being used to give anaesthesia for living donor liver transplant in our institute. Propofol when compared to isoflurane has advantages like early awakening from anaesthesia, reduced nausea, vomiting in the postoperative period. Propofol also has antioxidant properties. Because of its antioxidant properties propofol may have a protective effect against oxidative stress and ischemia reperfusion injury in major organs during liver transplant surgery. However, there are no studies showing the effect of isoflurane and propofol on Intraoperative hemodynamics and postoperative liver and kidney functions.Thus, we are conducting this study to know the effect of these agents on intraoperative hemodynamics and postoperative liver and kidney function.
Official title: Effect of Isoflurane and Target Control Infusion (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients: A Randomized Controlled Trial.
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-08-01
Completion Date
2024-10-31
Last Updated
2024-05-17
Healthy Volunteers
No
Conditions
Interventions
Target control infusion propofol
target control infusion of propofol for target plasma concentration 2.5mcg/ml and BIS 40-60
Inhalational isoflurane
Inhalational Isoflurane at concentration 1-2%
Locations (1)
Institute of liver and biliary sciences
Delhi, India