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Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw
Sponsor: University Hospital, Toulouse
Summary
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious side-effect of antiresorptive therapies used in the management of bone diseases, such as osteoporosis or bone metastases. A surgical management can lead to a resolution of the disease, but with perfectible results. For this purpose, the use of autologous platelet concentrates (APC) can be useful. With this study, researchers aim to demonstrate the efficacy of L-PRF (Leukocyte- and Platelet-Rich Fibrin) as an adjunct to the surgical treatment of MRONJ in terms of wound healing.
Official title: Use of Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw: a Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2024-05
Completion Date
2027-05
Last Updated
2024-05-17
Healthy Volunteers
No
Conditions
Interventions
Surgery with the use of L-PRF
The study protocol is the same as the standard surgery one but with additional use of L-PRF membranes
Standard surgery
The standard surgical treatment, taking place in the operating room under general anesthesia
Locations (7)
University Hospital - Centre François-Xavier Michelet
Bordeaux, France
University Hospital - Groupe hospitalier Pellegrin
Bordeaux, France
University Hospital
Limoges, France
University Hospital Gui de CHAULIAC
Montpellier, France
University Hospital Pitié-Salpêtrière
Paris, France
University Hospital
Toulouse, France
University Hospital
Toulouse, France