Clinical Research Directory

Inclusion Criteria for all study participants To be eligible for this study all study participants must meet the following: 1. Provide informed consent 2. Male or female, age 18-70 3. Ability to take an oral medication 4. Willingness and ability to do electronic surveys Additional inclusion criteria for Cohort 1 and Cohort 2 participants: 1. Must have Crohn's disease for at least 3 months 2. Must be on stable medication regimen for Crohn's disease for at least 4 weeks 3. Clinically quiescent Crohn's disease based on the Patient Reported Outcome -Crohn's Disease (PRO2) average score for up to 7 days - daily liquid or very soft stool frequency of ≤1.5 and abdominal pain ≤1.0 5.3 Additional inclusion criteria for Cohort 1 1\. Prescreening PROMIS Fatigue 7a T score \>60 5.4 Additional inclusion criteria for Cohort 2 and 3 1\. Prescreening PROMIS Fatigue 7a T score \<55 Exclusion Criteria - for all study participants 1. Pregnant or lactating - a blood pregnancy test will be administered - fatigue is common with pregnancy and the post-partum period and is more likely to be unrelated to Crohn's 2. Chronic fatigue syndrome - noted in the medical record or self-reported 3. Depression as measured with PROMIS Depression scale 7a with T score \>=60 4. New York Heart Association (NYHA) class 3 or greater heart failure - if noted in the medical record 5. Untreated sleep apnea 6. Abnormal Thyroid Stimulating Hormone (TSH) - \<0.45 μlU/mL or \>5.33 μlU/mL 7. Iron deficiency or anemia - ferritin \< 20 without anemia or \<100 with anemia (hemoglobin \< 12g/dL in females or 13.5 g/dL in males) on the screening laboratory tests 8. B12 deficiency - \<180 pg/mL on the screening laboratory tests 9. Stage 3B or higher Chronic Kidney Disease (CKD) - based on an estimated glomerular filtration rate (eGFR) \< 45 ml/min on the screening laboratory tests 10. Diagnosis of cirrhosis - if noted in the medical record or self-reported 11. Diagnosis of primary sclerosing cholangitis 12. Diagnosis with hepatitis C without evidence of successful eradication 13. Cancer and receiving chemotherapy - if noted in the medical record or self-reported 14. Multiple Sclerosis - self-reported on in chart. 15. Taking systemic corticosteroids (e.g. prednisone or budesonide), not including single doses given to prevent adverse reactions to a medication or contrast agent 16. Taking warfarin - if noted in the medical record or self-reported 17. Diabetes requiring medication - if noted in the medical record or self-reported 18. Symptoms of an infection in the last 2 weeks - self-reported 19. Any other comorbidity or condition that the PI thinks is a contraindication to participation in this study Exclusion Criteria for Cohorts 1 and 3 1\. Previous intolerance to CoQ10