Clinical Research Directory

Inclusion criteria: * Suspected obstructive coronary artery disease * No documented prior history of coronary artery disease * Clinical referral for invasive coronary angiography according to the referring clinician's decision * Competent adult (age ≥18 years) * Signed informed consent Exclusion criteria: * Acute coronary syndrome * History of coronary revascularization (percutaneous coronary intervention or coronary artery bypass grafting surgery) * History of coronary artery disease or acute coronary syndrome (myocardial infarction, unstable angina) * Use of sildenafil or dipyridamole that cannot be terminated * Pregnancy or lactation * Allergic reaction to iodized contrast * Concurrent or prior (within last 30 days) participation in other research studies using interventional drugs * Extensive comorbidities (i.e. cancer, other severe chronic diseases) * Contraindication for cardiac magnetic resonance with gadolinium-based contrast agent (including severe claustrophobia, magnetic resonance unsafe implants/devices or MR conditional devices not suitable for 3T scanner, severe renal failure with estimated glomerular filtration rate\<30 mL/min/1,73 m2, known hypersensitivity for gadolinium-based contrast agent) * Contraindications for adenosine usage (including hypersensitivity to adenosine/dipyridamole/regadenoson, second or third degree atrio-ventricular block, sick sinus syndrome, sinus bradycardia (heart rate \<40 bpm), long QT syndrome, severe hypertension (\> 220/120 mmHg), systolic blood pressure \<90mmHg, concomitant use of dipyridamole, severe asthma or severe chronic obstructive pulmonary disease)