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RECRUITING
NCT06420973
PHASE2

RC48 Treatment for Platinum Sensitive Recurrent Ovarian Cancer With HER2 Expression

Sponsor: Peking University Cancer Hospital & Institute

View on ClinicalTrials.gov

Summary

The purpose of this study is to evaluate the efficacy, safety, and quality of life scores of patients with HER2-expressing platinum-sensitive recurrent epithelial ovarian cancer treated with the combination therapy regimen of RC48 plus platinum with or without bevacizumab.

Official title: A Single-arm, Multicenter, Phase II Study of RC48 Plus Platinum With or Without Bevacizumab in the Treatment of HER-2 Expression Platinum-Sensitive Recurrent Ovarian Cancer

Key Details

Gender

FEMALE

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

54

Start Date

2024-05-16

Completion Date

2027-09-17

Last Updated

2024-05-20

Healthy Volunteers

No

Interventions

DRUG

RC48+carboplatin±bevacizumab

RC48 (2.5mg/kg iv on d1 , every 21d for 6 cycles) + Carboplatin (AUC5 iv on d1 every 21d for 6 cycles)±Bevacizumab (7.5-15mg/kg iv on d1 every 21d for 6 cycles) for treatment followed by RC48 (2.5mg/kg iv on d1 , every 21d for 8 cycles)±Bevacizumab (7.5-15mg/kg iv on d1 every 21d for progress ) maintenance therapy.

Locations (1)

Hong Zheng

Beijing, Beijing Municipality, China