Clinical Research Directory

Inclusion Criteria: * Age \> 18 years * Singleton pregnancy * Live fetus at 11-13 weeks of gestation * Pregnancies complicated by hypertensive disorders (HDP) and fetal growth restriction (FGR) Women with pregnancies complicated by HDP and a fetus with appropriate weight for gestational age (AGAf) * Women with pregnancies complicated solely by early fetal growth restriction (before 34 weeks) * Women with pregnancies complicated solely by late fetal growth restriction (after 34 weeks) * Women identified as high-risk in first-trimester screening for preeclampsia Women identified as high-risk in first-trimester screening for fetal growth restriction * Low-risk pregnancies in first-trimester screening for preeclampsia and fetal growth restriction, with physiological follow-up visits until delivery (homogeneous control sample) Exclusion Criteria: * Multiple pregnancies * Pregnancies complicated by major fetal abnormalities identified during the 11-13 week gestational assessment * Women who are unconscious or severely ill, women with learning difficulties, and those with severe psychiatric disorders * Age \<18 years * Women who have not provided informed consent for the study * Women with HIV, HBV, HCV infection * Women with a history of leukemia and lymphoma * Women with immunodeficiency * Women who have used corticosteroids or other immunosuppressants in the last 3 months