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Identifying Individuals at Risk of Glucocorticoid-Induced Impairment of Bone Disease
Sponsor: Odense University Hospital
Summary
Previous studies have shown that there is a large inter-individual variability in the degree of bone loss during glucocorticoid treatment, and while some patients experience extensive bone loss other patients\' bone mass remains stable. The aim of the study is to find a biomarker that can be used to identify individuals at risk of glucocorticoid-induced bone loss. The study will include 36 healthy volunteers, that will be randomized to receive either glucocorticoid treatment or placebo. During the study blood samples, bone marrow samples, bone tissue samples, and adipose tissue samples are taken and an oral glucose tolerance test is performed.
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2024-11-04
Completion Date
2026-04
Last Updated
2026-04-06
Healthy Volunteers
Yes
Conditions
Interventions
Prednisolone
prednisoline 25 mg/day for seven days
Placebo
Placebo treatment for seven days
Locations (2)
Hospital of South West Jutland
Esbjerg, Denmark
Odense University Hospital
Odense C, Denmark