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Neuromodulation Therapy for Task-Specific Dystonia
Sponsor: Duke University
Summary
This study aims to apply a non-invasive brain stimulation technology called repetitive Transcranial Magnetic Stimulation (rTMS) in patients with focal hand dystonia (FHD). The goal of the study is to identify which cortical target (premotor cortex (PMC) or primary somatosensory cortex (PSC)) will show benefit after active rTMS compared to sham rTMS. A secondary goal of the study is to understand if 10 Hz rTMS can show behavioral benefit compared to sham rTMS. The study will evaluate rTMS response using measures if writing on a sensor tablet, examiner and patient dystonia rating scales and brain imaging scan (functional MRI) to understand brain changes after rTMS. Safety measures include adherence to TMS guidelines and thorough medical screening to prevent seizures.
Official title: Development of Mechanistically Informed Therapy for Task-Specific Dystonia Using Noninvasive Neuromodulation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2018-08-23
Completion Date
2023-01-13
Last Updated
2026-04-13
Healthy Volunteers
Yes
Conditions
Interventions
Repetitive transcranial magnetic stimulation
10 Hz repetitive TMS will be delivered for 20 minutes per session and 0.7 Hz for 20 minutes per session
Locations (1)
Duke University Health System
Durham, North Carolina, United States