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An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures
Sponsor: University of Santiago de Compostela
Summary
Although controversy exists regarding the efficacy of antibiotic prophylaxis for patients at risk of infective endocarditis, expert committees continue to publish recommendations for antibiotic prophylactic regimens. The last American Heart Association (AHA) and European Society of Cardiology (ESC) guidelines include several important changes, highlighting that clindamycin (CLI) is no longer recommended as an alternative to amoxicillin in those allergic to penicillin. This new project aims to evaluate the effectiveness of oral doxycycline in preventing post-dental extraction bloodstream infection.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2024-07-15
Completion Date
2025-06-30
Last Updated
2024-06-17
Healthy Volunteers
No
Conditions
Interventions
Clindamycin
Receiving 600 mg oral Clindamycin 1 hour before general anesthesia and before any dental manipulation
Doxycycline
Receiving 100 mg oral Doxycycline 1 hour before general anesthesia and before any dental manipulation
Locations (1)
Santiago de Compostela University Hospital
Santiago de Compostela, A Coruña, Spain