Clinical Research Directory

Inclusion Criteria: * Must have been born in Japan, and their biological parents and grandparents must have been of Japanese origin * Has mean systolic office blood pressure (SBP) of \>130 and \<=165 mmHg by automated office blood pressure measurement, after a minimum of 3 weeks of washout if taking hypertensive medication * Has 24-hour mean SBP ≥130 mmHg by ambulatory blood pressure monitoring (ABPM), without antihypertensive medication Exclusion Criteria: * Has secondary hypertension, symptomatic orthostatic hypotension * Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>2× upper limit of normal (ULN) * Has elevated serum potassium \>5 mmol/L * Has estimated glomerular filtration rate (eGFR) of \<60 mL/min/1.73m\^2 * Has received an investigational agent within the last 30 days * Has Type 1 diabetes mellitus, poorly controlled Type 2 diabetes mellitus or newly diagnosed Type 2 diabetes mellitus * Has history of intolerance to SC injection(s)