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Insulin and Insulin Pulses During Fasting
Sponsor: Mayo Clinic
Summary
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.
Official title: Effect of Insulin and Insulin Pulses on Fasting Glucagon Secretion and on Glucose Metabolism in Subjects Without Type 2 Diabetes
Key Details
Gender
All
Age Range
25 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2024-09-15
Completion Date
2027-09-01
Last Updated
2025-10-01
Healthy Volunteers
Yes
Conditions
Interventions
Intralipid and heparin
Intralipid (20%, 0.011ml/kg/min; Baxter, Healthcare, Deerfield, IL) and heparin (200 units prime, 0.2 unit/kg/min continuous) will be infused to induce acute insulin resistance
Saline
Saline will be infused
Locations (1)
Mayo Clinic in Rochester
Rochester, Minnesota, United States