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Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes
Sponsor: Mayo Clinic
Summary
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.
Key Details
Gender
All
Age Range
25 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-04-01
Completion Date
2027-07-01
Last Updated
2025-04-15
Healthy Volunteers
Yes
Conditions
Interventions
Glucagon
a variable rate glucagon infusion
Glucose
a variable rate glucose infusion
Locations (1)
Mayo Clinic in Rochester
Rochester, Minnesota, United States