Clinical Research Directory

Inclusion Criteria: * Acute kidney injury treated by continuous renal replacement therapy in ICU less than 7 days, * At least 1 organ failure during ICU in addition to AKI (mechanical ventilation or vasopressors administration\>12 hours), * Cumulative UF net less than 1000ml before inclusion, * Norepinephrine \< 0,5 µg/kg/min, * Absence of hypoperfusion signs, * Fluid overload defined as follows: fluid overload \> 5% of base weight (based on cumulative fluid balance or a weight gain) and/or peripheral edema (AKIKI edema scale \> 2). Exclusion Criteria: * Chronic renal failure hemodialyzed before admission to the ICU, * Mechanical circulatory support (ECMO, LVAD), * Pregnant, child -bearing age or lactating women, * Stroke less than 30 days, * Intestinal ischemia less than 7 days documented non-operated, * Interventional study participation or exclusion period on going, * Guardianship, curatorship or safeguard of justice, * Absence of signature of free and informed consent by the patient and/or relative, * Patients not affiliated to a social security scheme or beneficiaries of a similar scheme * Absence of transpulmonary thermodilution monitoring